Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine.

@article{Zollner2003RoleON,
  title={Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine.},
  author={Gernot Zollner and Peter Fickert and Andrea Fuchsbichler and Dagmar Silbert and Martin Otto Werner Wagner and Silvia Arbeiter and Frank J. Gonzalez and Hanns-Ulrich Marschall and Kurt Zatloukal and Helmut Denk and Michael Trauner},
  journal={Journal of hepatology},
  year={2003},
  volume={39 4},
  pages={480-8}
}
BACKGROUND/AIMS Adaptive changes in transporter expression in liver and kidney provide alternative excretory pathways for biliary constituents during cholestasis and may thus attenuate liver injury. Whether adaptive changes in ATP-binding cassette (ABC) transporter expression are stimulated by bile acids and their nuclear receptor FXR is unknown. METHODS Hepatic, renal and intestinal ABC transporter expression was compared in cholic acid (CA)- and ursodeoxycholic acid (UDCA)-fed wild-type… CONTINUE READING
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