Role of nuclear IkappaB proteins in the regulation of host immune responses.

@article{Yamamoto2008RoleON,
  title={Role of nuclear IkappaB proteins in the regulation of host immune responses.},
  author={Masahiro Yamamoto and Kiyoshi Takeda},
  journal={Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy},
  year={2008},
  volume={14 4},
  pages={265-9}
}
A variety of microbial components activate a transcription factor called nuclear factor-kappaB (NF-kappaB) that plays an essential role in the optimal activation of host immune systems. The transcriptional activity of NF-kappaB is tightly regulated at multiple steps in immune signaling pathways, because excessive activation is detrimental to the host. One mechanism to prevent NF-kappaB activation is mediated by cytoplasmic IkappaB family proteins. Although cytoplasmic IkappaBs interact with NF… CONTINUE READING

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