Role of nrf2 in oxidative stress and toxicity.

  title={Role of nrf2 in oxidative stress and toxicity.},
  author={Qiang Ma},
  journal={Annual review of pharmacology and toxicology},
Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are traditionally viewed as being harmful. On the other hand, controlled production of oxidants in normal cells serves useful purposes to regulate signaling pathways. Reactive oxidants are counterbalanced by complex antioxidant defense systems regulated by a web of pathways to ensure that the response to oxidants is adequate… CONTINUE READING
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