Role of novel gyrA mutations in the suppression of the fluoroquinolone resistance genotype of vaccine strain Salmonella Typhimurium vacT (gyrA D87G).

@article{Preisler2006RoleON,
  title={Role of novel gyrA mutations in the suppression of the fluoroquinolone resistance genotype of vaccine strain Salmonella Typhimurium vacT (gyrA D87G).},
  author={Antje Preisler and Mobarak Abu Mraheil and Peter Heisig},
  journal={The Journal of antimicrobial chemotherapy},
  year={2006},
  volume={57 3},
  pages={430-6}
}
OBJECTIVES This study was aimed at characterizing the gyrA locus and determining its impact on fluoroquinolone susceptibility, DNA supercoiling degree and growth rate of Salmonella Typhimurium live vaccine strain vacT in comparison with its parent M415. Furthermore, the role of multiple drug resistance efflux in the susceptibility of vacT to fluoroquinolones and macrolides was investigated. METHODS DNA sequences were determined for genes gyrA, gyrB, parC and parE of M415 and three consecutive… CONTINUE READING

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Characterization of protective effects induced by oral immunization of pigs with an invasive gyrA-cpxA-rpoB Salmonella Typhimurium mutant

  • U Roesler, H Marg, I Schröder
  • Vaccine
  • 2004
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