Role of notch signaling in the maintenance of human mesenchymal stem cells under hypoxic conditions.

@article{Moriyama2014RoleON,
  title={Role of notch signaling in the maintenance of human mesenchymal stem cells under hypoxic conditions.},
  author={Hiroyuki Moriyama and Mariko Moriyama and Haruki Isshi and Shin Ishihara and Hanayuki Okura and Akihiro Ichinose and Toshiyuki Ozawa and Akifumi Matsuyama and Takao Hayakawa},
  journal={Stem cells and development},
  year={2014},
  volume={23 18},
  pages={2211-24}
}
Human adipose tissue-derived multilineage progenitor cells (hADMPCs) are attractive for cell therapy and tissue engineering because of their multipotency and ease of isolation without serial ethical issues. However, their limited in vitro lifespan in culture systems hinders their therapeutic application. Some somatic stem cells, including hADMPCs, are known to be localized in hypoxic regions; thus, hypoxia may be beneficial for ex vivo culture of these stem cells. These cells exhibit a high… CONTINUE READING
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