Role of nonselective cation current in muscarinic responses of canine colonic muscle.

@article{Lee1993RoleON,
  title={Role of nonselective cation current in muscarinic responses of canine colonic muscle.},
  author={Hyun Kyung Lee and Orline Bayguinov and Kenton M. Sanders},
  journal={The American journal of physiology},
  year={1993},
  volume={265 6 Pt 1},
  pages={C1463-71}
}
The mechanism of muscarinic excitation was studied in colonic muscle strips and isolated cells. In whole cell voltage-clamp studies performed at 33 degrees C utilizing the permeabilized patch technique, acetylcholine (ACh) reduced an L-type Ca2+ current. With K+ currents blocked, depolarization to positive potentials in the presence of ACh elicited outward current. Difference currents showed that ACh activated a voltage-dependent current that reversed at about -8 mV; this current (IACh) had… CONTINUE READING

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