Role of nonconserved charged residues of the AE2 transmembrane domain in regulation of anion exchange by pH

Abstract

The ubiquitous AE2/SLC4A2 anion exchanger is acutely and independently regulated by intracellular (pHi) and extracellular pH (pHo), whereas the closely related AE1/SLC4A1 of the red cell and renal intercalated cell is relatively pH-insensitive. We have investigated the contribution of nonconserved charged residues within the C-terminal transmembrane domain… (More)
DOI: 10.1007/s00424-007-0220-8

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