Role of non-neuronal cholinergic system in breast cancer progression.

  title={Role of non-neuronal cholinergic system in breast cancer progression.},
  author={Alejandro Javier Espa{\~n}ol and Eulalia de la Torre and Gabriel L Fiszman and Mar{\'i}a Elena Sales},
  journal={Life sciences},
  volume={80 24-25},
We have previously reported the expression of functional muscarinic acetylcholine receptors (mAChR) in two different murine mammary adenocarcinoma cell lines LM2 and LM3. Activation of mAChR with carbachol (CARB) increased proliferation in both tumor cell lines in a concentration-dependent manner. In LM3 cells CARB promoted proliferation via M(3) receptor activation by inositol 1,4,5-triphosphate and nitric oxide (NO) production. CARB-induced LM2 cells proliferation needed both M(2) and M(1… CONTINUE READING
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