Role of non-coding sequence variants in cancer

@article{Khurana2016RoleON,
  title={Role of non-coding sequence variants in cancer},
  author={Ekta Khurana and Yao Fu and Dimple Chakravarty and Francesca Demichelis and Mark A. Rubin and Mark B. Gerstein},
  journal={Nature Reviews Genetics},
  year={2016},
  volume={17},
  pages={93-108}
}
Patients with cancer carry somatic sequence variants in their tumour in addition to the germline variants in their inherited genome. Although variants in protein-coding regions have received the most attention, numerous studies have noted the importance of non-coding variants in cancer. Moreover, the overwhelming majority of variants, both somatic and germline, occur in non-coding portions of the genome. We review the current understanding of non-coding variants in cancer, including the great… 
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