Role of non-HLA genetic variants in end-stage renal disease.

  title={Role of non-HLA genetic variants in end-stage renal disease.},
  author={Prajnya Ranganath and Gaurav Tripathi and Ravi Kant Sharma and Satya Narayan Sankhwar and Suraksha Agrawal},
  journal={Tissue antigens},
  volume={74 2},
Cytokines and intercellular adhesion molecule (ICAM) play a crucial role in the pathogenesis of primary kidney disease and progression to end-stage renal disease (ESRD). Cytokine secretion is reported to be dependent on the single nucleotide polymorphisms located in the cytokine genes. The role of different polymorphisms in cytokines and ICAM genes as probable susceptibility factors for ESRD has been explored in the present study. The study was conducted on 258 ESRD patients and on ethnically… CONTINUE READING