Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis.

  title={Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis.},
  author={Shingo Kato and Yoshikazu Tsuzuki and Ryota Hokari and Yoshikiyo Okada and Junichi Miyazaki and Koji Matsuzaki and Atsuhiro Iwai and Atsushi Kawaguchi and Shigeaki Nagao and Kazuro Itoh and Hidekazu Suzuki and Toshitaka Nabeshima and Soichiro Miura},
  journal={Journal of neuroimmunology},
  volume={161 1-2},
Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR… CONTINUE READING


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The endogenous nociceptin/orphanin FQ-NOP receptor system as a potential therapeutic target for intestinal disorders.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society • 2014

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