Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats.

@article{Obrosova2007RoleON,
  title={Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats.},
  author={Irina G. Obrosova and Viktor R. Drel and Christine L. Oltman and Nazar Mashtalir and Jyoti Tibrewala and John T Groves and Mark A Yorek},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={293 6},
  pages={E1645-55}
}
Evidence for important roles of the highly reactive oxidant peroxynitrite in diabetic complications is emerging. We evaluated the role of peroxynitrite in early peripheral neuropathy and vascular dysfunction in STZ-diabetic rats. In the first dose-finding study, control and STZ-diabetic rats were maintained with or without the potent peroxynitrite decomposition catalyst Fe(III)tetrakis-2-(N-triethylene glycol monomethyl ether) pyridyl porphyrin (FP15) at 3, 5, or 10 mg.kg(-1).day(-1) in the… CONTINUE READING