Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.

@article{Pacher2005RoleON,
  title={Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.},
  author={P{\'a}l Pacher and Irina G. Obrosova and Jon G. Mabley and Csaba Szab{\'o}},
  journal={Current medicinal chemistry},
  year={2005},
  volume={12 3},
  pages={
          267-75
        }
}
Macro- and microvascular disease are the most common causes of morbidity and mortality in patients with diabetes mellitus. Diabetic cardiovascular dysfunction represents a problem of great clinical importance underlying the development of various severe complications including retinopathy, nephropathy, neuropathy and increase the risk of stroke, hypertension and myocardial infarction. Hyperglycemic episodes, which complicate even well-controlled cases of diabetes, are closely associated with… CONTINUE READING