Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats.

  title={Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats.},
  author={P Y Chen and Paul W. Sanders},
  volume={22 6},
Nitric oxide is a potent endogenous vasodilator that regulates arterial tone. A family of nitric oxide synthases uses L-arginine and L-homoarginine stereospecifically as substrates for nitric oxide production in vivo. By preventing expression of inducible but not constitutive nitric oxide synthases, glucocorticoids differentiate which enzyme in this family is the predominant source of nitric oxide generation in a given situation. We proposed that defective production of nitric oxide produces… CONTINUE READING
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