Role of nitric-oxide synthase isoforms in nitrous oxide antinociception in mice.

@article{Ishikawa2003RoleON,
  title={Role of nitric-oxide synthase isoforms in nitrous oxide antinociception in mice.},
  author={Masago Ishikawa and Raymond M. Quock},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={306 2},
  pages={
          484-9
        }
}
Exposure of mice to the anesthetic gas N2O evokes a prominent antinociceptive effect that is sensitive to antagonism by nonselective nitric-oxide synthase (NOS) inhibitors. The present study was conducted to identify whether a specific NOS isoform is implicated in N2O antinociception in mice. In the abdominal constriction test, exposure of mice to 25, 50, and 70% N2O resulted in a concentration-dependent antinociceptive effect that persisted for up to 6 min following removal of the mice from… CONTINUE READING

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