Role of nitric oxide production in carbachol-induced negative chronotropy in cultured rat ventricular myocytes.


It has been reported that nitric oxide (NO) plays a physiological role in mediating the effect of vagal stimulation in the autonomic regulation of the heart. In this study, the changes in NO production induced by carbachol were investigated by measuring the NO metabolites, nitrite (NO2-) and nitrate (NO3-), with a high-performance liquid chromatography… (More)