Role of nitric oxide in the regulation of HIF-1alpha expression during hypoxia.

@article{Agani2002RoleON,
  title={Role of nitric oxide in the regulation of HIF-1alpha expression during hypoxia.},
  author={Faton H. Agani and Michelle A. Puchowicz and Juan Carlos Chavez and Paola Pichiule and Joseph C. LaManna},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={283 1},
  pages={C178-86}
}
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor consisting of HIF-1alpha and HIF-1beta subunits, controls the expression of a large number of genes involved in the regulation of cellular responses to reduced oxygen availability. The oxygen-regulated subunit, HIF-1alpha, is stabilized in cells exposed to hypoxia. The regulation of… CONTINUE READING