Role of nitric oxide in the modulation of angiogenesis.

  title={Role of nitric oxide in the modulation of angiogenesis.},
  author={Lucia Morbidelli and Sandra Donnini and Marina Ziche},
  journal={Current pharmaceutical design},
  volume={9 7},
Angiogenesis, the development of new capillaries form pre-existing vessels, requires the coordinate activation of endothelial cells, which migrate and proliferate in response to growth factors to form functional vessels. Therapeutic angiogenesis is proposed to restore tissue integrity and function following damage and ischemia, while strategies aimed to block or suppress the neovascular growth are designed as adjuvant therapies for cancer treatment. Different experimental and clinical… CONTINUE READING


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