Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice.

Abstract

Effects of nitric oxide (NO) synthase inhibitors on the enoxacin-induced convulsions were examined in mice pretreated with fenbufen. 7-nitroindazole markedly suppressed the incidence of convulsions, whereas L-arginine did not modify the convulsions at all. The suppression of the convulsions by 7-nitroindazole was not reversed by the pretreatment of L-arginine. Brain NO synthase activity was significantly raised at 30 min after enoxacin when combined with fenbufen. The increased NO synthase activity was found to be suppressed by the pretreatment of 7-nitroindazole. These findings suggest that endogenous NO may be involved as a proconvulsant substance in the development of enoxacin-induced convulsions in mice pretreated with fenbufen.

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@article{Masukawa1998RoleON, title={Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice.}, author={Tohru Masukawa and Kuniaki Nakanishi and Reiko Natsuki}, journal={Japanese journal of pharmacology}, year={1998}, volume={76 4}, pages={425-9} }