Role of nitric oxide in regulation of renal sympathetic nerve activity during hemorrhage in conscious rats.

@article{Fujisawa1999RoleON,
  title={Role of nitric oxide in regulation of renal sympathetic nerve activity during hemorrhage in conscious rats.},
  author={Yoshihide Fujisawa and Naoko Mori and Kouichi Yube and Hiroshi Miyanaka and Akira Miyatake and Youichi Abe},
  journal={The American journal of physiology},
  year={1999},
  volume={277 1 Pt 2},
  pages={H8-14}
}
The effect of inhibition of nitric oxide (NO) synthesis on the responses of blood pressure (BP), heart rate (HR), and renal sympathetic nerve activity (RSNA) during hemorrhaging was examined with the use of an NO synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), in conscious rats. In the 0.9% saline group, hemorrhage (10 ml/kg body wt) did not alter BP but significantly increased HR and RSNA by 88 +/- 12 beats/min and 67 +/- 12%, respectively. Intravenous infusion of L-NAME (50… CONTINUE READING
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