Role of nitric oxide in obsessive-compulsive behavior and its involvement in the anti-compulsive effect of paroxetine in mice.

@article{Umathe2009RoleON,
  title={Role of nitric oxide in obsessive-compulsive behavior and its involvement in the anti-compulsive effect of paroxetine in mice.},
  author={Sudhir Niranjanrao Umathe and Pravinkumar Satyanarayan Bhutada and Nishant S. Jain and Yogita R. Mundhada and Shilpa S Borkar and Bhagyashree R. Dhumal},
  journal={Nitric oxide : biology and chemistry},
  year={2009},
  volume={21 2},
  pages={
          140-7
        }
}
In view of the reports that nitric oxide modulates the neurotransmitters implicated in obsessive-compulsive disorder, patients with obsessive-compulsive disorder exhibit higher plasma nitrate levels, and drugs useful in obsessive-compulsive disorder influence nitric oxide, we hypothesized that nitric oxide may have some role in obsessive-compulsive behavior. We used marble-burying behavior of mice as the animal model of obsessive-compulsive disorder, and nitric oxide levels in brain homogenate… CONTINUE READING
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Animal models of obsessive-compulsive disorder: Exploring pharmacology and neural substrates

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Current animal models of obsessive compulsive disorder: an update

  • Neuroscience
  • 2012
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