Role of nitric oxide in muscle regeneration following eccentric muscle contractions in rat skeletal muscle

@article{Sakurai2013RoleON,
  title={Role of nitric oxide in muscle regeneration following eccentric muscle contractions in rat skeletal muscle},
  author={Tomonobu Sakurai and Osamu Kashimura and Yutaka Kano and Hideki Ohno and Li Li Ji and Tetsuya Izawa and Thomas M. Best},
  journal={The Journal of Physiological Sciences},
  year={2013},
  volume={63},
  pages={263-270}
}
We examined the role of nitric oxide (NO) in muscle repair and regeneration following repetitive eccentric contractions (ECC). A standardized exercise protocol was used to create eccentric contraction-induced injury to the left tibialis anterior muscle of 48 male Wistar rats (body wt 250–350 g), using a customized isokinetic test device and a bout of 40 ECCs under electrical stimulation. A nitric oxide synthase inhibitor, N(G)-nitro-l-arginine-methyl ester (l-NAME; 35 mg kg−1 day−1), was… CONTINUE READING
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