Role of nitric oxide in liver injury.

  title={Role of nitric oxide in liver injury.},
  author={Tracy Chen and Ruben Zamora and Brian S Zuckerbraun and Timothy R Billiar},
  journal={Current molecular medicine},
  volume={3 6},
The complex role of nitric oxide (NO) in the liver can be explained by its patterns of regulation and unique biochemical properties. With a broad range of direct and indirect molecular targets, NO acts as an inhibitor or agonist of cell signaling events. In the liver, constitutively generated NO maintains the hepatic microcirculation and endothelial integrity, while inducible NO synthase (iNOS)-governed NO production can be either beneficial or detrimental. For instance, NO potentiates the… CONTINUE READING
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