Role of nitric oxide in immune responses against viruses: beyond microbicidal activity

  title={Role of nitric oxide in immune responses against viruses: beyond microbicidal activity},
  author={Elaine Uchima Uehara and Beatriz de Stefano Shida and C. A. de Brito},
  journal={Inflammation Research},
  • Elaine Uchima Uehara, Beatriz de Stefano Shida, C. A. de Brito
  • Published 2015
  • Biology, Medicine
  • Inflammation Research
  • IntroductionNitric oxide (NO) is a free radical produced during l-arginine metabolism. In addition to its physiological activities in vascular and neuronal functions, its role in the immune system as a microbicide and tumor-killing mediator has been well described, as well as its release by activated macrophages. Furthermore, NO is produced by a variety of immune and non-immune cells and is involved in the regulation of several immune functions, such as T-cell polarization and suppression… CONTINUE READING
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