Role of nitric oxide in Sjögren's syndrome.

  title={Role of nitric oxide in Sj{\"o}gren's syndrome.},
  author={Yrj{\"o} T. Konttinen and Louise A M Platts and Susanna Tuominen and Kari K Eklund and Nina Santavirta and Jyrki T{\"o}rnwall and Timo Sorsa and Mika V J Hukkanen and Julia M P Polak},
  journal={Arthritis and rheumatism},
  volume={40 5},
OBJECTIVE To measure levels of salivary nitrite (NO2-) and to localize nitric oxide synthases (NOS) in the labial salivary glands (LSGs) of patients with Sjögren's syndrome (SS). METHODS NO2- was measured by the Griess reaction. LSGs were analyzed using NADPH-diaphorase histochemical and immunohistochemical studies to determine the constitutive NOS (neuronal [ncNOS] and endothelial [ecNOS]) and inducible NOS (iNOS) isoforms. RESULTS The NO2- concentration (mean +/- SEM 307 +/- 51 microM… CONTINUE READING
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