Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat.

@article{Hayakawa1999RoleON,
  title={Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat.},
  author={Hiroshi Hayakawa and Yasunobu Hirata and Masao Kakoki and Yasuko Suzuki and Hiroaki Nishimatsu and Daisuke Nagata and Etsu Suzuki and Kazuya Kikuchi and Tetsuo Nagano and Kenji Kangawa and Hisayuki Matsuo and Taro Sugimoto and Masao Omata},
  journal={Hypertension},
  year={1999},
  volume={33 2},
  pages={689-93}
}
We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aortic rings and perfused kidneys isolated from Wistar rats. We also measured NO release from the kidneys… CONTINUE READING
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