Role of nitric oxide as a mediator of internal anal sphincter relaxation.

@article{Rattan1992RoleON,
  title={Role of nitric oxide as a mediator of internal anal sphincter relaxation.},
  author={Satish Rattan and Sushanta Chakder},
  journal={The American journal of physiology},
  year={1992},
  volume={262 1 Pt 1},
  pages={G107-12}
}
The studies were performed in in vitro to examine the role of nitric oxide (NO) in nonadrenergic noncholinergic (NANC) nerve-mediated relaxation of the internal anal sphincter (IAS) smooth muscle strips of opossums. NO caused a concentration-dependent fall in the resting tension of the IAS. The inhibitory action of NO may be exerted directly on the IAS smooth muscle since it was not modified by the neurotoxin tetrodotoxin (1 x 10(-6) M), which abolished the neurally mediated fall in the IAS… CONTINUE READING