Role of nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia

@article{Matsubara2010RoleON,
  title={Role of nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia},
  author={Keiichi Matsubara and Yuko Matsubara and S. Hyodo and Tomihiro Katayama and Masaharu Ito},
  journal={Journal of Obstetrics and Gynaecology Research},
  year={2010},
  volume={36}
}
Aim:  Preeclampsia is characterized by a disruption of general vascular dilatation, which is mainly mediated by nitric oxide (NO) and disturbed by reactive oxygen species (ROS). The present study investigated the roles of NO and ROS in the pathogenesis of preeclampsia. 
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Nitric Oxide and Reactive Oxygen Species in the Pathogenesis of Preeclampsia
TLDR
New insights are provided about roles of oxidative stress in the pathophysiology of PE and placental ischemia in PE decreases the antioxidant activity resulting in further elevated oxidative stress, which leads to the appearance of the pathological conditions of PE including hypertension and proteinuria.
Radicals, Oxidative/Nitrosative Stress and Preeclampsia.
TLDR
Current literature about researches demonstrating the interplay between oxidative, nitrosative stresses and PE, about their roles in the pathophysiology of PE and also about the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation are reviewed.
Oxidative Stress in Preeclampsia and Placental Diseases
TLDR
This review presents the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models, and assess the putative effects of these free radicals on the placenta and maternal endothelium.
Endothelial dysfunction and preeclampsia: role of oxidative stress
TLDR
Current literature from research showing the interplay between oxidative stress, ED and PE to the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation is reviewed.
New views on endothelial dysfunction in gestational hypertension and potential therapy targets.
Oxidative stress in pregnancy complicated by preeclampsia.
The NOX2-derived reactive oxygen species damaged endothelial nitric oxide system via suppressed BKCa/SKCa in preeclampsia
TLDR
This study indicated that the increased oxidative stress in preeclamptic HUVECs could downregulate the NO system by suppressing BKCa and SKCa channels and mediated by NADPH (nicotinamide adenine dinucleotide phosphate) oxidase 2 (NOX2)-dependent reactive oxygen species overproduction that couldDownregulate whole-cell K+ currents, eNOS expression and NO production.
The role of arginine, homoarginine and nitric oxide in pregnancy
Normal pregnancy leads to profound maternal hemodynamic changes, including increased blood volume and vasodilatation. Several vasodilator mediators are implicated, including prostaglandins, carbon…
Magnesium sulfate therapy of preeclampsia: an old tool with new mechanism of action and prospect in management and prophylaxis
A disturbed balance between angiogenic and antiangiogenic growth factors is a highly accepted mechanism in the pathogenesis of pregnancy-induced hypertension and proteinuria, which is clinically…
Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia.
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