Role of nitric oxide and protein kinase C in ACh-induced cardioprotection.

@article{Liu2001RoleON,
  title={Role of nitric oxide and protein kinase C in ACh-induced cardioprotection.},
  author={Howard H.T. Liu and Bradley C. McPherson and Xuehai Zhu and Mark da Costa and V Jeevanandam and Zhenhai Yao},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 1},
  pages={
          H191-7
        }
}
We examined the roles of nitric oxide and protein kinase C (PKC) in ACh-produced protection of cultured cardiomyocytes during simulated ischemia and reoxygenation. Cell viability was quantified using propidium iodide in chick embryonic ventricular myocytes. O(2) radicals were quantified using 2',7'-dichlorofluorescin diacetate. After a 10-min infusion of ACh (0.5 or 1 mM) and a 10-min drug-free period, we simulated ischemia for 1 h and reoxygenation for 3 h. ACh reduced cardiocyte death [32… CONTINUE READING

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