Role of nitric oxide and flavohemoglobin homolog genes in Aspergillus nidulans sexual development and mycotoxin production.

@article{Baidya2011RoleON,
  title={Role of nitric oxide and flavohemoglobin homolog genes in Aspergillus nidulans sexual development and mycotoxin production.},
  author={Sachin Baidya and Jeffrey W. Cary and W. Scott Grayburn and Ana M Calvo},
  journal={Applied and environmental microbiology},
  year={2011},
  volume={77 15},
  pages={5524-8}
}
Flavohemoglobins are widely distributed in both prokaryotes and eukaryotes. These proteins are involved in reducing nitric oxide levels. Deletion of the Aspergillus nidulans flavohemoglobin gene fhbA induced sexual development and decreased sterigmatocystin production. Supplementation with a nitric oxide-releasing compound promoted cleistothecial formation and increased nsdD and steA expression, indicating that nitric oxide induces sexual development. This is the first study on the effect of… CONTINUE READING

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