Role of nitric oxide and cGMP system in regulation of ductus arteriosus tone in ovine fetus.

@article{Fox1996RoleON,
  title={Role of nitric oxide and cGMP system in regulation of ductus arteriosus tone in ovine fetus.},
  author={Jonathan J Fox and James W Ziegler and D Dunbar Ivy and Ann C. Halbower and John P. Kinsella and Steven H Abman},
  journal={The American journal of physiology},
  year={1996},
  volume={271 6 Pt 2},
  pages={H2638-45}
}
Although endogenous nitric oxide (NO) modulates basal tone in the fetal pulmonary and systemic circulations, little is known about its role in regulating ductus arteriosus (DA) tone. Immunostaining of DA tissue from late-gestation fetal lambs demonstrated strong staining for endothelial NO synthase (eNOS) in DA endothelium. To study the physiological role of the NO and guanosine 3',5'-cyclic monophosphate (cGMP) system in the DA in vivo, we measured the hemodynamic effects of NG-nitro-L… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

The Pharmacology of the Ductus Arteriosus

GORDON C. S. SMITHa
1998
View 10 Excerpts
Highly Influenced

The pharmacology of the ductus arteriosus.

Pharmacological reviews • 1998
View 11 Excerpts
Highly Influenced

Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse.

American journal of physiology. Regulatory, integrative and comparative physiology • 2004
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…