Role of nitric oxide and adenosine in control of coronary blood flow in exercising dogs.

@article{Tune2000RoleON,
  title={Role of nitric oxide and adenosine in control of coronary blood flow in exercising dogs.},
  author={Johnathan D. Tune and Keith Neu Richmond and Mark W. Gorman and Eric O. Feigl},
  journal={Circulation},
  year={2000},
  volume={101 25},
  pages={2942-8}
}
BACKGROUND Inhibition of nitric oxide (NO) synthesis results in very little change in coronary blood flow, but this is thought to be because cardiac adenosine concentration increases to compensate for the loss of NO vasodilation. Accordingly, in the present study, adenosine measurements were made before and during NO synthesis inhibition during exercise. METHODS AND RESULTS Experiments were performed in chronically instrumented dogs at rest and during graded treadmill exercise before and… CONTINUE READING

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