Role of nitric oxide, tetrahydrobiopterin and peroxynitrite in glucose toxicity-associated contractile dysfunction in ventricular myocytes

Abstract

Local overproduction of nitric oxide is seen in early stages of diabetes, which can react with superoxide (O2 −) to form peroxynitrite (ONOO−). The aim of this study was to examine the effect of scavengers for nitric oxide, O2 −, ONOO− and NOS cofactor tetrahydrobiopterin (BH4) on high glucose-induced cardiac contractile dysfunction. Ventricular myocytes… (More)
DOI: 10.1007/s00125-003-1183-8

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@article{Esberg2003RoleON, title={Role of nitric oxide, tetrahydrobiopterin and peroxynitrite in glucose toxicity-associated contractile dysfunction in ventricular myocytes}, author={Lucy B. Esberg and Dr. Jun Ren}, journal={Diabetologia}, year={2003}, volume={46}, pages={1419-1427} }