Role of nicotinic acetylcholine receptors in cell proliferation and tumour invasion in broncho-pulmonary carcinomas.

@article{Medjber2015RoleON,
  title={Role of nicotinic acetylcholine receptors in cell proliferation and tumour invasion in broncho-pulmonary carcinomas.},
  author={Kahina Medjber and Mohamed Lamine Freidja and Simon Grelet and Marianne Lorenzato and Kamel Maouche and B{\'e}atrice Nawrocki-Raby and Philippe Birembaut and Myriam Polette and Jean-Marie Tournier},
  journal={Lung cancer},
  year={2015},
  volume={87 3},
  pages={258-64}
}
OBJECTIVES Nicotine and its associated nicotinic acetylcholine receptors (nAChRs) are believed to be involved in the progression of lung carcinomas. This study aimed at examining the localization of nAChRs in human lung tumours and, by using primary cultures of tumour cells derived from these tumours, determining the nAChR roles in cell proliferation and tumour invasion. MATERIALS AND METHODS Immunohistochemistry was used to assess nAChR expression in non-small cell lung carcinomas (NSCLC… CONTINUE READING
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