Role of neurotoxin associated proteins in the low pH induced structural changes in the botulinum neurotoxin complex.

@article{Chellappan2014RoleON,
  title={Role of neurotoxin associated proteins in the low pH induced structural changes in the botulinum neurotoxin complex.},
  author={Gowri Chellappan and Raj Kumar and Shuowei Cai and Bal Ram Singh},
  journal={The protein journal},
  year={2014},
  volume={33 6},
  pages={557-64}
}
Botulinum Neurotoxin (BoNT) produced by the bacterium Clostridium botulinum as a complex with NAPs causes botulism. It has been known that the NAPs protect the toxin from both extremes of pHs and proteases of the GI tract. In an attempt to emulate the physiological conditions encountered by the toxin, we examined BoNT/A, BoNT/A complex, and NAPs under… CONTINUE READING