Role of neuropeptide Y and peroxisome proliferator-activated receptor γ coactivator-1α in stress cardiomyopathy

@article{Ananda2012RoleON,
  title={Role of neuropeptide Y and peroxisome proliferator-activated receptor γ coactivator-1α in stress cardiomyopathy},
  author={Sunnassee Ananda and Yunyun Wang and Shaohua Zhu and Rongshuai Wang and Xiaowei Zhou and L. S. Zhuo and Tingyi Sun and Liang Ren and Qian Liu and Hongmei Dong and Yan Liu and Liang Liu},
  journal={Journal of Huazhong University of Science and Technology [Medical Sciences]},
  year={2012},
  volume={32},
  pages={823-828}
}
SummaryDeath following situations of intense emotional stress has been linked to the cardiac pathology described as stress cardiomyopathy, whose pathomechanism is still not clear. In this study, we sought to determine, via an animal model, whether the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC-1α) and the amino peptide neuropeptide Y (NPY) play a role in the pathogenesis of this cardiac entity. Male Sprague-Dawley rats in the experimental… CONTINUE READING