Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish

@article{Braida2013RoleON,
  title={Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish},
  author={Daniela Braida and Luisa Ponzoni and Roberta Martucci and Fabio Sparatore and Cecilia Gotti and Mariaelvina Sala},
  journal={Psychopharmacology},
  year={2013},
  volume={231},
  pages={1975-1985}
}
RationaleNeuronal nicotinic acetylcholine receptors (nAChRs) play a modulatory role in cognition, and zebrafish provide a preclinical model to study learning and memory.ObjectivesWe investigated the effect of nicotine (NIC) and some new cytisine-derived partial agonists (CC4 and CC26) on spatial memory in zebrafish using a rapid assay on T-maze task. The role of α4/α6β2 and the α7 nAChRs in NIC-induced memory enhancement was evaluated using selective nAChR antagonists.ResultsLow and high doses… Expand
The cytisine derivatives, CC4 and CC26, reduce nicotine-induced conditioned place preference in zebrafish by acting on heteromeric neuronal nicotinic acetylcholine receptors
TLDR
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The data suggest an involvement of cholinergic signaling in aversive learning in zebrafish models, reinforcing the growing utility of zebra fish models to explore the neurobehavioral effects of nicotine in vertebrates. Expand
Chapter 2 Zebrafi sh : An Animal Model to Study Nicotinic Drugs on Spatial Memory and Visual Attention
Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in learning and memory in both humans and animals. For their physical characteristics, including small size, easiness to grow, andExpand
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The results suggest that prenatal exposure to AFCAs may lead to sex-dependent alterations in glutamatergic signaling which may continue into adolescence, which is implicated in the etiology of certain childhood hyperactivity and learning disabilities. Expand
Behavioural and pharmacological profiles of zebrafish administrated pyrrolidinyl benzodioxanes and prolinol aryl ethers with high affinity for heteromeric nicotinic acetylcholine receptors
TLDR
Behavioural studies indicate that full agonist prolinol aryl ethers are very active in increasing spatial learning, memory and attention in zebrafish. Expand
NAChR α4β2 subtype and their relation with nicotine addiction, cognition, depression and hyperactivity disorder.
BACKGROUND Neuronal α4β2 nAChRs are receptors involved in the role of neurotransmitters regulation and release, and this ionic channel participates in biological process of memory, learning andExpand
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Recent data revealing the potential of the zebrafish model to evaluate the effects and molecular mechanisms of nicotine by taking into consideration its impact on anxiety, learning and memory, addiction and social behaviours are presented. Expand
Anxiogenic-like effects of chronic nicotine exposure in zebrafish
TLDR
Chronic 4-day exposure to 1-2mg/L nicotine mildly increased adult zebrafish shoaling but did not alter baseline cortisol levels, and it was found that chronic exposure to nicotine evokes robust anxiogenic behavioral responses in zebra fish tested in the novel tank test paradigm. Expand
Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments
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