Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish

  title={Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish},
  author={Daniela Braida and Luisa Ponzoni and Roberta Martucci and Fabio Sparatore and Cecilia Gotti and Mariaelvina Sala},
RationaleNeuronal nicotinic acetylcholine receptors (nAChRs) play a modulatory role in cognition, and zebrafish provide a preclinical model to study learning and memory.ObjectivesWe investigated the effect of nicotine (NIC) and some new cytisine-derived partial agonists (CC4 and CC26) on spatial memory in zebrafish using a rapid assay on T-maze task. The role of α4/α6β2 and the α7 nAChRs in NIC-induced memory enhancement was evaluated using selective nAChR antagonists.ResultsLow and high doses… 

Nutrient combinations exhibit universal antianxiety, antioxidant, neuro-protecting, and memory-improving activities

Anxiety disorders are the most common mental disorders and, without proper treatment, may lead to severe conditions: e.g., somatic disorders or permanent damage to central nervous system. Although

Prenatal Hypoxia-Induced Adverse Reaction to Mild Stress is Associated with Depressive-Like Changes in the Glucocorticoid System of Rats.

Prenatal hypoxia causes depression-like patterns in the brain glucocorticoid system with adverse reaction to mild stressors, and in response to MS, PSH rats demonstrate mild changes in their activity, while in control animals the MS-induced activity of the glucoc Corticoid System is similar to intact PSH animals.

Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM)

JW XY capsule was more effectively than sertraline in rescuing reserpine-induced depression and cognitive disorder in zebrafish and can provide new insights into the clinical treatment of depression and the mechanism of action of JWXY capsule.

An ancient conserved role for prion protein in learning and memory

An age-dependent memory decline in prp2−/− zebrafish is document, pointing to a conserved and ancient role of PrPC in memory, and the learning paradigm established here enables a path forward to study PrPC interactions of relevance to Alzheimer's disease and prion diseases, and to screen for candidate therapeutics for these diseases.

α7 nicotinic ACh receptor‐deficient mice exhibit sustained attention impairments that are reversed by β2 nicotinic ACh receptor activation

ACh in the prefrontal cortex regulates attentive behaviour; however, the role of α7 nicotinic ACh receptor (α7nAChR) in attention is contentious.

The cytisine derivatives, CC4 and CC26, reduce nicotine-induced conditioned place preference in zebrafish by acting on heteromeric neuronal nicotinic acetylcholine receptors

CC4 and CC26 induced CPP with an inverted U-shaped dose–response curve similar to that of NIC, however, when co-administered with NIC, they blocked its reinforcing or slightly aversive effect.



The role of α7 and α4β2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish

Nicotine response genetics in the zebrafish

A nicotine behavioral assay in zebrafish is developed and applied in a forward genetic screen using gene-breaking transposon mutagenesis, and it is shown this insertional method generates mutant alleles that are reversible through Cre-mediated recombination, representing a conditional mutation system for the zebra fish.

Behavioral screening for cocaine sensitivity in mutagenized zebrafish

  • T. DarlandJ. Dowling
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
It is reported that zebrafish exhibit cocaine-induced conditioned place preference and performance profiles in secondary behavioral screens measuring visual dark-adaptation and learning suggest that the defects were the result of mutations in distinct genes that affect dopaminergic signaling in the retina and brain.

Intraperitoneal Injection into Adult Zebrafish

The utility of IP injection is demonstrated by injecting glucose and monitoring the rise in blood glucose level and its subsequent return to normal and as stress is known to increase blood glucose in teleost fish, a comparison of blood glucose levels in vehicle-injected and non-injection adults is compared and it is shown that the procedure does not cause a significant rise inBlood glucose levels.

Nicotinic involvement in memory function in zebrafish.

A simple spatial alternation task for assessing memory function in zebrafish

Enhancement of Attentional Performance by Selective Stimulation of α4β2* nAChRs: Underlying Cholinergic Mechanisms

The combined behavioral and electrochemical evidence supports the hypothesis that nAChR agonist-evoked cholinergic transients, which are characterized by rapid rise time and fast decay, predict robust drug-induced enhancement of attentional performance.

Nicotine effects on learning in zebrafish: the role of dopaminergic systems

Dopamine systems are related to learning in zebrafish; nicotine exposure increases both learning rates and DOPAC levels; and nicotinic antagonist administration blocks nicotine-induced rises in DOPac concentrations.