Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish

@article{Braida2013RoleON,
  title={Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish},
  author={Daniela Braida and Luisa Ponzoni and Roberta Martucci and Fabio Sparatore and Cecilia Gotti and Mariaelvina Sala},
  journal={Psychopharmacology},
  year={2013},
  volume={231},
  pages={1975-1985}
}
RationaleNeuronal nicotinic acetylcholine receptors (nAChRs) play a modulatory role in cognition, and zebrafish provide a preclinical model to study learning and memory.ObjectivesWe investigated the effect of nicotine (NIC) and some new cytisine-derived partial agonists (CC4 and CC26) on spatial memory in zebrafish using a rapid assay on T-maze task. The role of α4/α6β2 and the α7 nAChRs in NIC-induced memory enhancement was evaluated using selective nAChR antagonists.ResultsLow and high doses… 

The cytisine derivatives, CC4 and CC26, reduce nicotine-induced conditioned place preference in zebrafish by acting on heteromeric neuronal nicotinic acetylcholine receptors

CC4 and CC26 induced CPP with an inverted U-shaped dose–response curve similar to that of NIC, however, when co-administered with NIC, they blocked its reinforcing or slightly aversive effect.

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