Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish
@article{Braida2014RoleON, title={Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish}, author={Daniela Braida and Luisa Ponzoni and Roberta Martucci and Fabio Sparatore and Cecilia Gotti and Mariaelvina Sala}, journal={Psychopharmacology}, year={2014}, volume={231}, pages={1975-1985} }
RationaleNeuronal nicotinic acetylcholine receptors (nAChRs) play a modulatory role in cognition, and zebrafish provide a preclinical model to study learning and memory.ObjectivesWe investigated the effect of nicotine (NIC) and some new cytisine-derived partial agonists (CC4 and CC26) on spatial memory in zebrafish using a rapid assay on T-maze task. The role of α4/α6β2 and the α7 nAChRs in NIC-induced memory enhancement was evaluated using selective nAChR antagonists.ResultsLow and high doses…
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