Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia.

@article{Wei1999RoleON,
  title={Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia.},
  author={Gang Wei and Valina L Dawson and Jay L. Zweier},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1455 1},
  pages={23-34}
}
Nitric oxide (NO) plays an important role in the pathogenesis of neuronal injury during cerebral ischemia. The endothelial and neuronal isoforms of nitric oxide synthase (eNOS, nNOS) generate NO, but NO generation from these two isoforms can have opposing roles in the process of ischemic injury. While increased NO production from nNOS in neurons can cause neuronal injury, endothelial NO production from eNOS can decrease ischemic injury by inducing vasodilation. However, the relative magnitude… CONTINUE READING

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