Role of neuroinflammation and latent transcription factors in pathogenesis of Parkinson's disease.

@article{Pal2016RoleON,
  title={Role of neuroinflammation and latent transcription factors in pathogenesis of Parkinson's disease.},
  author={Rishi Pal and Prafulla Chandra Tiwari and Rajendra Nath and Kamlesh Kumar Pant},
  journal={Neurological research},
  year={2016},
  volume={38 12},
  pages={1111-1122}
}
Parkinson's disease (PD) the second most common age-associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons, cytoplasmic inclusions of aggregated proteins (Lewy bodies), and neuroinflammation. The inflammation of neurons causes release of various inflammatory mediators (IFNs, EGF, IL5, IL6, HGF, LIF and BMP2). The hallmarks of neuroinflammation are the presence of activated microglia and reactive astrocytes in the parenchyma of the CNS and increased… CONTINUE READING

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Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
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The hallmarks of neuroinflammation are the presence of activated microglia and reactive astrocytes in the parenchyma of the CNS and increased production of cytokines , chemokines , prostaglandins , complement cascade proteins , and reactive oxygen and nitrogen species ( ROS / RNS ) which in some cases can result in disruption of the blood brain barrier and direct participation of the adaptive immune system .
Parkinson 's disease ( PD ) the second most common age - associated progressive neurodegenerative disorder is characterized by loss of dopaminergic neurons , cytoplasmic inclusions of aggregated proteins ( Lewy bodies ) , and neuroinflammation .
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