Role of neuro-immunological factors in the pathophysiology of mood disorders

@article{Bhattacharya2016RoleON,
  title={Role of neuro-immunological factors in the pathophysiology of mood disorders},
  author={Anindya Bhattacharya and No{\"e}l C. Derecki and Timothy W. Lovenberg and Wayne C. Drevets},
  journal={Psychopharmacology},
  year={2016},
  volume={233},
  pages={1623-1636}
}
Mood disorders, despite the widespread availability of monoamine-based antidepressant treatments, are associated with persistently high rates of disability, together with elevated rates of mortality due to suicide, cardiovascular disease, and other causes. The development of more effective treatments has been hindered by the lack of knowledge about the etiology and pathogenesis of mood disorders. An emerging area of science that promises novel pathways to antidepressant and mood stabilizing… 

Figures from this paper

Role of Neuro-Immunological Factors in the Pathophysiology of Mood Disorders: Implications for Novel Therapeutics for Treatment Resistant Depression.
TLDR
Evidence that the compounds that reduce the release or signaling of neuroactive cytokines, particularly IL-1β, IL-6, and TNF-α, can exert antidepressant effects in subgroups of depressed patients who are identified by blood-based biomarkers associated with inflammation is reviewed.
Immune-based strategies for mood disorders: facts and challenges
TLDR
The evidence showing low-grade inflammation in mood disorders and the studies evaluating immune-based strategies for the treatment of these conditions are reviewed.
Biological hypotheses and biomarkers of bipolar disorder
TLDR
Current biological hypotheses of BD are summarized, including related pathophysiological processes and key biomarkers, which have been associated with changes in genetics, systems of neurotransmitter and neurotrophic factors, neuroinflammation, autoimmunity, cytokines, stress axis activity, chronobiology, oxidative stress, and mitochondrial dysfunctions.
The role of adenosine receptors in mood and anxiety disorders
TLDR
The results discussed here indicate that the adenosinergic system is involved in both the etiology and the treatment of mood and anxiety disorders.
Immune targets for therapeutic development in depression: towards precision medicine
TLDR
A framework for developing drugs targeting a novel patient subtype within MDD is outlined, the current state of neuroimmune drug development for mood disorders is reviewed and evidence for a causal role of immune mechanisms in the pathogenesis of depression is discussed.
Is There a Future for PPARs in the Treatment of Neuropsychiatric Disorders?
TLDR
Running findings in support of a role for PPARs in the treatment of neurological diseases, including Alzheimer’s disease or psychiatric disorders, such as major depression are reviewed.
Potential of Glial Cell Modulators in the Management of Substance Use Disorders
TLDR
The paper reviews the pre-clinical and clinical studies assessing the effects that glial modulators have on abuse-related behavioral effects, such as pleasure, withdrawal, and motivation and presents a brief overview of each of the major classes of addictive drugs on glia.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 146 REFERENCES
The role of the innate immune system in psychiatric disorders
Inflamed moods: A review of the interactions between inflammation and mood disorders
Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression.
  • J. Koo, R. Duman
  • Psychology, Biology
    Current opinion in investigational drugs
  • 2009
TLDR
This review highlights the increasing interest in the relationship between IL-1 beta, neurogenesis, stress and depression, and discusses the potential ofIL-1Ra or other cytokine antagonists as new candidates for the treatment of depression.
Insights from interferon-α-related depression for the pathogenesis of depression associated with inflammation
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
A review of the relationship between proinflammatory cytokines and major depressive disorder.
Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation?
Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes.
TLDR
This finding is important for improving treatment because it implies that therapeutics that reduce microglial activation should be promising for MDE and is consistent with the concept that neuroinflammation in specific regions may contribute to sickness behaviors that overlap with the symptoms of MDE.
Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder
TLDR
This review will discuss the most recent research surrounding novel compounds with primary mechanisms of action on the glutamatergic, cholinergic and opioid systems, and discusses novel device-based therapeutics, with a particular focus on transcranial magnetic stimulation.
Neuroinflammation and psychiatric illness
TLDR
The link between autoimmunity and neuropsychiatric disorders, and the human and experimental evidence supporting the pathogenic role of neuroinflammation in selected classical psychiatric disorders are reviewed.
...
1
2
3
4
5
...