Role of natural killer cytotoxic factors in the mechanism of target-cell killing by natural killer cells

@article{Bonavida1986RoleON,
  title={Role of natural killer cytotoxic factors in the mechanism of target-cell killing by natural killer cells},
  author={Benjamin Bonavida and Susan C. Wright},
  journal={Journal of Clinical Immunology},
  year={1986},
  volume={6},
  pages={1-8}
}
Studies on the mechanism of cell-mediated cytotoxicity (CMC) have suggested a stimulus-secretion model and implicated a role of soluble cytotoxic mediators. Our studies in the natural killer (NK) system provide several lines of evidence for the involvement of natural killer cytotoxic factors (NKCF) in NK CMC and led to the development of a model for the NK lytic mechanism. This model delineates several interactions between NK cells and targets that are deemed necessary to achieve target-cell… CONTINUE READING