Role of myosin light chain kinase and myosin light chain phosphatase in the resistance arterial myogenic response to intravascular pressure.

@article{Cole2011RoleOM,
  title={Role of myosin light chain kinase and myosin light chain phosphatase in the resistance arterial myogenic response to intravascular pressure.},
  author={William C. Cole and Donald G. Welsh},
  journal={Archives of biochemistry and biophysics},
  year={2011},
  volume={510 2},
  pages={160-73}
}
The intrinsic ability of vascular smooth muscle cells (VSMCs) within arterial resistance vessels to respectively contract and relax in response to elevation and reduction of intravascular pressure is essential for appropriate blood flow autoregulation. This fundamental mechanism, referred to as the myogenic response, is dependent on apposite control of myosin regulatory light chain (LC(20)) phosphorylation, a prerequisite for force generation, through the coordinated activity of myosin light… CONTINUE READING