Role of myosin heavy chain composition in kinetics of force development and relaxation in rat myocardium.

@article{Fitzsimons1998RoleOM,
  title={Role of myosin heavy chain composition in kinetics of force development and relaxation in rat myocardium.},
  author={Daniel P. Fitzsimons and Jitandrakumar R. Patel and Richard L Moss},
  journal={The Journal of physiology},
  year={1998},
  volume={513 ( Pt 1)},
  pages={171-83}
}
1. The effects of ventricular myosin heavy chain (MHC) composition on the kinetics of activation and relaxation were examined in both chemically skinned and intact myocardial preparations from adult rats. Thyroid deficiency was induced to alter ventricular MHC isoform expression from approximately 80% alpha-MHC/20% beta-MHC in euthyroid rats to 100% beta-MHC, without altering the expression of thin-filament-associated regulatory proteins. 2. In single skinned myocytes, increased expression of… CONTINUE READING

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