Role of myoplasmic phosphate in contractile function of skeletal muscle: studies on creatine kinase-deficient mice.

@article{Dahlstedt2001RoleOM,
  title={Role of myoplasmic phosphate in contractile function of skeletal muscle: studies on creatine kinase-deficient mice.},
  author={Anders J Dahlstedt and Abram Katz and H{\aa}kan Westerblad},
  journal={The Journal of physiology},
  year={2001},
  volume={533 Pt 2},
  pages={379-88}
}
1. Increased myoplasmic inorganic phosphate (P(i)) has been suggested to have an important role in skeletal muscle fatigue, especially in the early phase. In the present study we used intact fast-twitch muscle cells from mice completely deficient in creatine kinase (CK(-/-)) to test this suggestion. These CK(-/-) muscle cells provide a good model since they display a higher P(i) concentration in the unfatigued state and fatigue without significant increase of P(i). 2. Tetanic contractions (350… CONTINUE READING

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