Role of myoglobin in the antioxidant defense of the heart.

  title={Role of myoglobin in the antioxidant defense of the heart.},
  author={Ulrich Floegel and Axel Goedecke and Lars-Oliver Klotz and Juergen Schrader},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={18 10},
Although the primary function of myoglobin (Mb) has been considered to be cellular O2 storage and supply, recent studies have shown that Mb in addition can act as NO oxidase. Here we report that Mb also significantly contributes to the attenuation of oxidative stress in cardiac muscle. In support of this hypothesis, we found that in isolated perfused hearts of Mb-deficient (myo-/-) mice oxidative challenge by intracoronary infused H2O2 (1-300 microM) or superoxide formed by 2,3-dimethoxy-1,4… CONTINUE READING
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