Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis.

@article{Ferrara2010RoleOM,
  title={Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis.},
  author={Napoleone M. A. Ferrara},
  journal={Current opinion in hematology},
  year={2010},
  volume={17 3},
  pages={219-24}
}
PURPOSE OF REVIEW Targeting the vascular endothelial growth factor (VEGF) pathway has had a significant impact in the therapy of cancer and intraocular neovascular disorders. Similar to other therapies, inherent/acquired resistance to anti-VEGF drugs may occur in cancer patients, leading to disease recurrence. This review describes recent findings on the role of myeloid cells in refractoriness or/and acquired resistance to such therapies. RECENT FINDINGS Various myeloid cell types, including… CONTINUE READING
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