Role of mutator alleles in adaptive evolution

@article{Taddei1997RoleOM,
  title={Role of mutator alleles in adaptive evolution},
  author={François Taddei and Miroslav Radman and J. Maynard-Smith and Bruno Toupance and Pierre Henri Gouyon and Bernard Godelle},
  journal={Nature},
  year={1997},
  volume={387},
  pages={700-702}
}
Because most newly arising mutations are neutral or deleterious, it has been argued that the mutation rate has evolved to be as low as possible, limited only by the cost of error-avoidance and error-correction mechanisms. But up to one per cent of natural bacterial isolates are ‘mutator’ clones that have high mutation rates. We consider here whether high mutation rates might playan important role in adaptive evolution. Models of large, asexual, clonal populations adapting to a new environment… CONTINUE READING
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