Role of mutations identified in ORFs M56 (terminase), M70 (primase) and M98 (endonuclease) in the temperature-sensitive phenotype of murine cytomegalovirus mutant tsm5.

@article{Timoshenko2009RoleOM,
  title={Role of mutations identified in ORFs M56 (terminase), M70 (primase) and M98 (endonuclease) in the temperature-sensitive phenotype of murine cytomegalovirus mutant tsm5.},
  author={Olga Timoshenko and Abdulaziz Taher Al-Ali and Brian A B Martin and Clive Sweet},
  journal={Virology},
  year={2009},
  volume={392 1},
  pages={114-22}
}
Twenty-six non-synonymous and synonymous mutations have been identified in the temperature-sensitive (ts) mutant (tsm5) of the K181 (Birmingham) variant of murine cytomegalovirus that is deficient in DNA synthesis, processing and packaging at the non-permissive temperature and produces undetectable levels of infectious virus in mice. Non-synonymous… CONTINUE READING