Role of multiplex FISH in identifying chromosome involvement in myelodysplastic syndromes and acute myeloid leukemias with complex karyotypes: a report on 28 cases.

@article{BaroukSimonet2005RoleOM,
  title={Role of multiplex FISH in identifying chromosome involvement in myelodysplastic syndromes and acute myeloid leukemias with complex karyotypes: a report on 28 cases.},
  author={Emmanuelle Barouk-Simonet and Val{\'e}rie Soenen-Cornu and Christophe Roumier and Alain Cosson and Jean-Luc La{\"i} and Pierre Fenaux and Claude Joseph Preudhomme},
  journal={Cancer genetics and cytogenetics},
  year={2005},
  volume={157 2},
  pages={118-26}
}
Chromosomal abnormalities are found by conventional cytogenetic (CC) analysis in about 50% of myelodysplastic syndromes (MDS) and 70% of acute myeloid leukemias (AML). When cytogenetic abnormalities are complex, multiplex fluorescence in situ hybridization (M-FISH) can help clarify complex chromosomal abnormalities and identify rearrangements with prognostic value or cryptic translocations, which could be preliminary steps in identifying new genes. We studied by M-FISH 28 cases of MDS and AML… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…